|
|
4-hydroxybutyrate + NAD+ <=> succinate_semialdehyde + NADH + H+
|
1.1.1.2
alcohol dehydrogenase (NADP+)
1.1.1.21
aldose reductase
1.1.1.61
4-hydroxybutyrate dehydrogenase
1.1.1.79
glyoxylate reductase (NADP+)
1.1.1.B47
|
–
–
–
–
–
|
BMK
|
|
BRENDA:
BR29325
KEGG:
R01644
MetaCyc:
4-HYDROXYBUTYRATE-DEHYDROGENASE-RXN
SABIO-RK:
1781
|
|
|
|
4-hydroxybutyrate + ATP + CoA <=> 4-hydroxybutanoyl-CoA + AMP + diphosphate
|
6.2.1.40
4-hydroxybutyrate---CoA ligase (AMP-forming)
|
–
|
BMK
|
|
BRENDA:
BR51010
KEGG:
R09279
MetaCyc:
RXN-9092
|
|
|
|
NADP+ + 4-hydroxybutyrate <=> H+ + NADPH + succinate_semialdehyde
|
1.1.1
1.1.1.19
glucuronate reductase
1.1.1.2
alcohol dehydrogenase (NADP+)
1.1.1.26
glyoxylate reductase
1.1.1.61
4-hydroxybutyrate dehydrogenase
1.1.1.79
glyoxylate reductase (NADP+)
1.1.1.B47
1.1.1.co
|
–
–
–
–
–
–
–
–
|
BMK
|
|
BRENDA:
BR51069
KEGG:
R09281
MetaCyc:
RXN-11002
SABIO-RK:
10705
|
|
|
|
4-hydroxybutyrate + ATP + CoA <=> 4-hydroxybutanoyl-CoA + ADP + phosphate
|
6.2.1.56
4-hydroxybutyrate---CoA ligase (ADP-forming)
|
–
|
MK
|
|
BRENDA:
BR52705
KEGG:
R10758
MetaCyc:
RXN-18387
|
|
|
|
2-oxoglutarate + 4-hydroxybutyrate <=> succinate_semialdehyde + (R)-2-hydroxyglutarate
|
1.1.99.24
hydroxyacid-oxoacid transhydrogenase
|
–
|
|
|
BRENDA:
BS189010
MetaCyc:
RXN-14300
SABIO-RK:
10878
|
|
|
|
acetyl-CoA + 4-hydroxybutyrate <=> acetate + 4-hydroxybutanoyl-CoA
|
2.8.3
2.8.3.1
propionate CoA-transferase
|
–
–
|
BMK
|
|
BRENDA:
BS425667
KEGG:
R05336
MetaCyc:
RXN-8889
|
|
|
|
4-hydroxybutyrate + acetoacetyl-CoA <=> 4-hydroxybutanoyl-CoA + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358838
SABIO-RK:
11118
|
|
|
|
4-hydroxybutyrate + NAD+ <=> acetoacetate + NADH
|
1.1.1.30
3-hydroxybutyrate dehydrogenase
|
–
|
|
|
BRENDA:
BS383900
|
|
|
|
L-3-hydroxybutyrate + succinate_semialdehyde <=> acetoacetate + 4-hydroxybutyrate
|
1.1.99.24
hydroxyacid-oxoacid transhydrogenase
|
–
|
|
|
BRENDA:
BS189012
|
|
|
|
4-hydroxybutyrate + 2-oxoglutarate <=> succinate_semialdehyde + 2-hydroxyglutarate
|
1.1.99.24
hydroxyacid-oxoacid transhydrogenase
|
–
|
|
|
BRENDA:
BS189009
|
|